Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD Running Title: EPHX1 and GCL variation in COPD
نویسندگان
چکیده
1 The University of Nottingham. Division of Clinical Chemistry, Molecular Medical Sciences, Institute of Genetics, University Hospital, Queens Medical Centre, Nottingham, NG7 2UH, UK 2 University College Dublin. UCD School of Public Health & Population Science, UCD, Belfield, Dublin 4, IRELAND 3 Hospital Clinico y Provincial de Barcelona. Service de Pneumologia, Hospital Clinic, Villarroel, 170, 08036, Barcelona, SPAIN. 4 University of Bristol. Lung Research Group, Department of Clinical Science at North Bristol, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, UK 5 University College Dublin. UCD School of Medicine and Medical Science, The Conway Institute, UCD, Belfield, Dublin 4, IRELAND 6 Letterkenny General Hospital, Letterkenny, Co. Donegal, Ireland . Published on July 9, 2008 as doi: 10.1183/09031936.00065308 ERJ Express
منابع مشابه
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD.
The genetic factors that contribute to the development of chronic obstructive pulmonary disease (COPD) are poorly understood. Many candidate genes have been proposed, including enzymes that protect the lung against oxidative stress, such as microsomal epoxide hydrolase (EPHX1) and glutamate-cysteine ligase (GCL). To date, most reported findings have been for EPHX1, particularly in relation to f...
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We tested the hypothesis that two well-characterised functional polymorphisms of the microsomal epoxide hydrolase gene (EPHX1), T113C and A139G, may influence susceptibility to chronic obstructive pulmonary disease (COPD) and asthma. We genotyped participants from the Copenhagen City Heart Study (n = 10,038) and the Copenhagen General Population Study (n = 37,022) for the T113C and A139G varian...
متن کاملMicrosomal epoxide hydrolase gene polymorphisms and risk of chronic obstructive pulmonary disease: A comprehensive meta-analysis
Microsomal epoxide hydrolase (EPHX1) is an enzyme involved in the detoxification the products of smoking and is proposed to be a genetic factor for the development of chronic obstructive pulmonary disease (COPD). Two functional polymorphisms of EPHX1, T113C and A139G, have been analyzed in numerous studies to assess the COPD risk attributed to these variants. However, the conclusions were contr...
متن کاملGenetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD.
Genetic susceptibility to the development of chronic obstructive pulmonary disease (COPD) might depend on variation in the activities of enzymes that detoxify cigarette smoke products, such as microsomal epoxide hydrolase (mEPHX) and glutathione S-transferase (GST). It was investigated whether polymorphisms in these genes had any association with susceptibility to COPD and COPD severity. The ge...
متن کاملEffect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes
BACKGROUND The role of the antioxidant N-acetylcysteine (NAC) in the treatment of chronic obstructive pulmonary disease (COPD) has not been clarified as yet. In early studies, we found that the proportion of smokers with COPD having extremely slow/slow microsomal epoxide hydrolase (EPHX1) enzyme activity is significantly higher than that in healthy smokers. The purpose of this study was to eval...
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